Metabolic inhibition potentiates oxidant injury
نویسندگان
چکیده
منابع مشابه
Metabolic inhibition potentiates oxidant injury.
Toxic oxygen species have been implicated as important mediators of injury after reperfusion of an ischemic organ. The aim of this study was to determine if prior metabolic inhibition, such as that which occurs during ischemia, potentiates oxidant injury in vitro. Bovine pulmonary artery endothelial cells were metabolically inhibited for various periods of time with or without the mitochondrial...
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AIMS Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans. We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in adult mice. The present studies tested the hypothesis that TrxR1 inhibition protects against the effects of hyperoxia via nuclear factor E2-related factor 2 (Nrf2)-dependent mech...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 1991
ISSN: 0022-4804
DOI: 10.1016/0022-4804(91)90197-t